The study examined selected thermal comfort indices over Oluyole Industrial region in Ibadan, Oyo State, Nigeria. Specific objectives were to describe the thermal condition of the selected industrial region and examine the relationship between the unitary and integrative indices over the area. Temperature and relative humidity data were collected using a whirling psychrometer. Dew point temperature and heat index or humidex temperature (temperature felt by the skin rather than the actual temperature due to the humidity level) were calculated by using Fanger’s formula in an NOAA’s weather calculator. The study showed that average temperature was 35.2oC while average relative humidity was 51%, and the dewpoint temperature and heat index were 22.8oC and 41.9oC, respectively. Dewpoint temperature was shown to relate stronger with heat index, and lesser with either air temperature or relative humidity. The study concluded that residents in the industrial region are likely to feel warmer than the ambient air temperature, and this is associated with the effect of the industrial activities in the area. The study recommends greening of the industrial area for effective reduction of the heat stress in industrial region. It also suggests policy for adequate monitoring of industrial region for significant temperature change.