The study examined perception and attitude towards media sensitization on COVID19 safety measures among residents of Ondo State, Nigeria during the COVID-19 first wave. Data for the study were collected from a sample of 528 residents through online questionnaire. Findings showed that the media have been very active in championing the fight against COVID-19 spread through its sensitization campaign and a very large number of Ondo State residents were exposed to such sensitization with many of them (respondents) being able to recall the issues raised in the campaign. Also, respondents’ perception of the government’s measure to prevent the spread of COVID-19 is positively skewed. However, while respondents agree with government’s directives on COVID-19 protocol, such agreement minimally influenced their attitude as majority of them did not comply with some of the directives to curb the spread. It is recommended that the media should involve credible and respected people who are opinion leaders in the society to help in the sensitization message.