This paper examined the various factors in Intellectual Disability, and family residence with special focus on Down’s syndrome type. A descriptive survey research design was employed in the study. Simple random sampling technique was adopted to select 291 participants from Ibadan, Oyo state (150 males and 141 females). Two research questions were raised and multiple regression analysis was used to anelyse the data collected from the administered validated Down Syndrome Type Questionnaire (DSTQ; α = 87). The results obtained, revealed that independent variables (chromosomal abnormalities, mother’s age, heredity, ignorance in marriage incompatibility and environmental agents) when put together, yielded a co-efficient of multiple regression 0.37 and multiple correlation square of 0.247, this indicated that 25% of the total variance in participants disposition to Intellectual Disability of Down’s Syndrome type is accounted for by the combination of the five variables that is significant at 0.05 level (f 95.502; P, 0.05). Also, each of the independent variable except environmental agents made significant individual contribution to the prediction of Intellectual Disability of Down’s syndrome type. The researcher reported a correlation between mother’s age and Down syndrome incidence, hence, it was recommended that prospective mothers should get pregnant before the age of 35 years. Equally emphasized is the importance of medical tests and other preventive measures towards curbing the incidence of Down’s syndrome in the family.