The problem of mental health in women, especially women working within the academia, is an important area of study that has received little attention among researchers. Bearing dual responsibilities at the home front and workplace may place serious mental health issues among this population. This study examined the influence of personality traits, social support and dispositional optimism on the mental health of married women in University of Ibadan. Using the Social model and Attribution theory, the study utilized the expost facto research design with primary data collected from married women employed at the University of Ibadan. The sampling technique adopted was the purposive sampling technique with a total sample size of 381 participants. Data was analyzed using t-test for independent measures and the Multiple Linear Regression analytical tools at 0.05 level of significance. Results revealed that extraversion, conscientiousness, social support and dispositional optimism are important independent and joint predictors of mental health among married women in the University of Ibadan. Recommendations were made in this regard.