The study's purpose was to examine the relationship among of inflation, manufacturing sector and economic growth in Nigeria over the period 1980 to 2017 using econometrics analysis (Ordinary Least Square (OLS)). The study performed several pre- test and post-test: such as unit root, co-integration, etc. and it was confirmed that the spurious relationship and serial correlation do not exist among the adopted variables for this study. The ECT was correctly signed and the result showed that there is insignificant inverse relationship between inflation and GDP in one hand and insignificant direct relationship between manufacturing output and economic growth in another. The Enger Granger Causality test indicated that no causal relationship existed between inflation and economic growth or economic growth to inflation. However, causal relationship existed between manufacturing out and economic growth. This implies that as manufacturing productivity increases, it tends to increase economic growth in Nigeria in the years under study. The paper recommended that inflationary rate must be monitored and curtailed to a single digit so that growth can be sustained, diversification of the economy to enhance the performance of the manufacturing sector activities in Nigeria.